The COBI RCT
"Effect of Continuous Infusion of Hypertonic Saline vs Standard Care on 6-Month Neurological Outcomes in Patients With Traumatic Brain Injury: The COBI Randomized Clinical Trial"
by Antoine Roquilly et al.
JAMA. 2021 May 25;325(20):2056-2066. doi: 10.1001/jama.2021.5561.PMID: 34032829
Conclusions: Among patients with moderate to severe traumatic brain injury, treatment with continuous infusion of 20% hypertonic saline compared with standard care did not result in a significantly better neurological status at 6 months. However, confidence intervals for the findings were wide, and the study may have had limited power to detect a clinically important difference.
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